Endocrine Abstracts

The way to maleness is a long process starting with fertilization when sperm delivers the testis-determining Y chromosome to the oocyte and ending with puberty and the action of testicular hormones. Since Sertoli cells are at the crossroads of the entire process, the analysis of the factors driving their differentiation and function is essential to the global understanding of male sexual development. By using mouse functional genetics, we will show that growth factors of the i...